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Professor researches potential allergy treatment

first_imgBasar Bilgicer, assistant professor in the Department of Chemical and Biomolecular Engineering and Advanced Diagnostics and Therapeutics Initiative, said groundbreaking scientific advances have taken a step towards preventative treatment possible for millions of Americans who suffer from life-threatening allergies. He said he and his team have made progress towards the first-ever inhibitory therapy for Type I Hypersensitive allergic reactions.  “These type of allergies are potentially lethal,” he said. “Unfortunately, there are no available medications that can prevent the occurrence of an allergic response to … Type I allergies.”  Type I hypersensitive responses occur by the components of the immune system designed to fight harmful parasites when mast cells and basophils, both of which are types of white blood cells, respond to harmless allergens with symptoms that can be as devastating as potentially lethal anaphylactic shock, Bilgicer said.  The only treatments currently available for severe allergies, like an EpiPen, attempt to manage symptoms until a victim can be taken to the hospital, Bilgicer said.  Bilgicer, also part of the Center for Rare and Neglected Diseases and the Harper Cancer Center, said his team of Notre Dame researchers are working on the  design and synthesis of Heterobivalent Inhibitors (HBI), which bind more effectively to mast cells and basophils than allergens like shellfish and peanuts. “Our approach is to stop it before it takes place,” Bilgicer said. “Our molecules are designed so that they will compete with the allergen molecule in binding to the receptor in mast cells and basophils. Our molecule binds more effectively, blocking binding of allergens and keeping allergic reactions from happening in the first place.” He said HBI molecules have worked successfully in cellular and animal tests in mice, and although all the ideas were developed at Notre Dame, his group has been in collaboration with Dr. Mark Kaplan’s at Indiana University (IU).  “We did all the design and synthesis here,” Bilgicer said. “The animal studies were verified at IU Med School in Dr. Kaplan’s lab.”  This allergy research has been in development since Bilgicer joined the Notre Dame faculty in 2008, and he said Dr. Michael Handlogten, a recently graduated PhD student, worked as the leading scientist on the project since its initiation. Bilgicer said the most updated version of these advances, included the findings from the mice studies, were published in the Nature Chemical Biology Journal.  Bilgicer said Notre Dame partly funded his research, but the project also received support from the National Institute of Health’s National Institute of Allergic and Infections Diseases.  Society increasingly needs this groundbreaking inhibitory treatment, as Type I allergies become more prevalent, Bilgicer said.  “At present, there is a strong prevalence of peanut allergies, unfortunately,” he said. “The number of cases is increasing.”. People could eventually use Bilgicer’s HPI research with severe allergies in multiple ways, he said. First, it could work to replace an EpiPen if symptoms of a reaction begin to occur. It could also be used if an exposure to a deadly allergen is likely, like when sending a child to school, he said. “If you are allergic to peanuts and you know you are getting on a flight, you could take an HPI,” he said. “The dust from the guy next to you opening a bag of peanuts can cause deadly reactions, which has happened before.” He said another important usage could be in Immunotherapy, which involves slow exposure to an allergen so that they body gradually learns that the allergen is not actually harmful, eventually leading to tolerance. Currently, he said most Type I allergy sufferers cannot safely be exposed to any amount of their allergen. “We could give the allergen in presence of HPI to control the effects of the allergen and reduce the symptoms for a patient,” he said. “Therefore, HBI can potentially be used in conjunction with immunotherapy to treat Type I hypersensitivity.” Bilgicer said he plans to develop a specific HPI for each type of allergen that causes Type I allergic reactions.  “The next step is to take this away from model system and into a system where it would be more relevant to natural allergens,” he said. “The HBI needs to be redesigned for every new allergen. To inhibit, say, peanuts we have to make a new HBI, and that is the next step in our research.” Contact Abi Hoverman at ahoverma@nd.edulast_img read more

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Watch Frozen’s Santino Fontana, Idina Menzel, Kristen Bell & Josh Gad Perform Live

first_img Santino Fontana Star Files Idina Menzel View Comments Princes and queens and snowmen, oh my! We don’t know if we’re elated or gassy, but we’re somewhere in that zone because the stars of Frozen are all over the place. We didn’t think today could get any better after finding out that Idina Menzel will be performing “Let It Go” at the Academy Awards, but then we stumbled upon video of Frozen’s other stars joking around and performing at L.A.’s Vibrato Grill Jazz Club. Check out Josh Gad (Olaf), Santino Fontana (Hans) and Kristen Bell (Anna) reprising their animated roles and singing songs, including “In Summer” and “Love is an Open Door.” Josh Gad Disney’s Frozenlast_img read more

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Younger Recap: Fasten Your Fur Bikini, It’s Going to Be a Bumpy Night

first_img You know that feeling when you’re standing in the middle of Times Square wearing a fur bikini and your daughter shows up? It’s weird, right? Naturally, that’s far from the strangest thing to happen to Liza Miller in this week’s Younger. Secrets are exposed, new romances are ignited and lawsuits are probably being made against the City of New York. You may need a hard hat for this one.SEASON 2, EPISODE 11: “Secrets & Lizas”Emoji UpdateLiza aims to tell her daughter Caitlin about her job (which we suppose is a step), but decides to put it off until later that evening. At Empirical, everyone is running around preparing for the arrival of Edward L.L. Moore (Richard Masur), author of Game of Thrones Crown of Kings. The last novel of the epic series will be released the next night, so it’s obviously the perfect time for Edward to cast unassuming Liza as Princess Pam Pam for the Times Square event. At a company dinner, Edward aggressively flirts with Liza, and in doing so, reveals some major spoilers about the book. The next day, Kelsey begs Liza to spill the beans on the Crown of Kings ending, including who dies, because someone big always dies. Thad keeps texting Liza because Liza still has that sex tape of him and his co-worker and is threatening to tell Kelsey if he doesn’t himself. Thad, in an attempt to go head to head with her, goes to Brooklyn, where he meets Liza’s daughter…who indeed introduces herself as Liza’s daughter. Oops. At the book launch, Liza is decked out in her Princess Pam Pam finest: a fur bikini. Caitlin, still in the dark on Liza’s job, tracks her down, and in a surprisingly sweet moment, shows immense gratitude for everything her mom’s doing. We have to hand it to Liza: for someone who loves to avoid the truth, she handles potential conflict very well. Meanwhile, Thad does some investigating and through Dartmouth’s alumni page, discovers Liza’s secret. After the event, Liza and Charles grab a drink, and just as things are starting to head toward a definitive #TeamCharles moment, she gets a text from Thad, who knows her whole deal. The next day, Liza confronts Thad, and just after she tells him off, promises to tell Kelsey about his affair and that she doesn’t care who he tells about her age, he gets hit by a falling construction piece from a crane. Someone big always dies, right?Biggest OMG Moment:We’ll admit we’ve never been #TeamThad, but the final scene of this week’s episode was harsh. Sure, he’s a himbo, but he’s a lovable himbo. And he looks so cute holding kittens! But if you threaten Liza, you summon the wrath of the sky. Er, the wrath of airborne steel beams.Millennial Glossary:Cyber-Tracker(noun) A type of app that allows you to locate mobile devices using GPS. Especially handy if you misplace your phone…or if your mom is wearing a fur bikini in the middle of Times Square and you need to find her.Moment That Made Us Go:Here’s what we wanted to do to Edward L.L. Moore every time he threatened to “eat” Liza, handed his hotel card to Liza or spoke to Liza. Hands to yourself, Edward, lest Princess Pam Pam summons the wrath of the sky. Or something. She controls lightning, OK?Diana’s Statement Jewelry Update!Looks like someone is a little too excited for 10 Cloverfield Lane. Or maybe the rerelease of Bambi? We’re getting major extraterrestrial deer vibes from Diana’s statement necklace this week. Wait…is that Professor Snape’s Patronus around her neck?! View Comments Sutton Foster in ‘Younger'(Photo: TV Land)last_img read more

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Fire ant invaders

first_imgVegetable gardens and compost piles are usually located in the sunniest part of the landscape. Unfortunately, fire ants like sunshine as well. They often invade compost piles and vegetable gardens seeking food, warmth and moisture.In the gardenAnts are usually of little or no concern to most vegetable plants, but during periods of hot, dry weather they will sometimes feed on select plants — either nibbling on okra buds and developing pods or even tunnel into potatoes. Ants are considered beneficial insects that prey on garden pests like caterpillars. However, seeing ants on your plants may be a clue of another more serious insect problem — aphids. Some ants protect other sap-feeding insects, like aphids, by keeping their natural enemies away. The ants then harvest honeydew from the aphids as a food source. This interaction between ants and aphids is known as a “symbiotic relationship.” In the compost binFire ants most often invade compost bins after someone abandons or neglects the composting process. Fire ants usually avoid places that are disturbed. A compost pile that is frequently turned won’t be attractive to these biting critters. Ants in a compost pile can also be a sign that the pile is too dry. This can slow down the composting process. Compost piles stay hotter and are more productive when frequently turned and proper moisture levels are maintained. A compost pile that reaches higher temperatures in the early stages of composting may also discourage fire ants. RemovalOnce the ants become established in a garden or compost pile, it may be difficult to remove them. If they persist or become a nuisance, pour boiling water on the nest. Use extreme caution as this method can potentially be very dangerous to you and your garden plants. This rarely eradicates the colonies, but it may cause them to move to a new location. As a last resort, use fire ant bait killer near — but not in — the compost pile or garden. Insecticides applied to a compost pile may kill other beneficial insects that are involved in the composting process. Avoid direct application of pesticides on the compost pile and follow the pesticide label’s instructions. Use pesticides labeled for the location or site you want to treat. For example, do not use a product in a vegetable garden unless the product is labeled for use in vegetable gardens. Carbaryl, pyrethrins and spinosad are common insecticides labeled as safe for use in vegetable gardens. When the exact location of a fire ant colony is unknown, treat the area of greatest ant activity around the perimeter of your garden or compost pile with a fast-acting bait product containing hydramethylnon, abamectin, indoxacarb or spinosad. In time foraging ants both inside and outside the garden will collect the bait and take it to their colonies.Removing fire ants from your garden and compost pile will protect you from being bitten.For more information on fire ant control, see the University of Georgia Cooperative Extension publication “Controlling Fire Ants in Urban Areas” at www.caes.uga.edu/publications.last_img read more

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GAW accelerates New England expansion with acquisition of SNEWISP

first_imgSNEWISP was formed to provide affordable and reliable broadband Internet service to the many NewEngland communities having trouble getting a quality, high-speed Internet connection; a vision sharedby GAW. Noted Justin Leland, SNEWISPS’s General Manger, “We are thrilled to become part of GAWand look forward to being able to provide service to many more New Englanders, all backed by thesupport of local customer service associates, working out of local offices and call centers.”Commented GAW CEO Josh Garza, “This is an exciting step in GAW’s continued expansion from itsroots in rural Vermont to the urban centers of New England. We are delighted to have the opportunityto serve customers in Massachusetts and Connecticut and anticipate investing heavily in networkexpansion in order to offer digital telephone service alongside faster broadband speeds” GAW was formed in 2005 and provides Internet service using fixed wireless technology to subscribersin Vermont and New Hampshire on a network that defies rough terrain and topography. Operating inboth rural and urban areas, GAW and its related companies are the proud recipients of the largestnumber of Vermont state grants for the provision of broadband service to under-served communities.For more information about GAW or to find out if we serve your community, please visit us atwww.GAW.com(link is external) or call us at 877-220-2873. About GAWcenter_img GAW High Speed Internet Inc., (GAW) Vermont’s largest Wireless Internet provider announced todaythe acquisition of Southern New England Wireless Internet Service Provider LLC, (SNEWISP).Headquartered in Springfield, MA, SNEWISP provides an important broadband connection forbusinesses and residences in and around Southern New England’s thriving five college community andthe beautiful Berkshire mountain range, home to some the world’s great artists and innovators. TheSNEWISP network has visibility to over one million people, extending west to Worcester, MA and southto Hartford, CT.last_img read more

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Leadership development is NOT a “one-off!”

first_img 4SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr,Jim Bouchard “THE SENSEI LEADER is not just another leadership development program. It is a movement.”Our programs support this movement and help us fulfill our vision and mission…                                                                     Vision: To promote … Web: TheSenseiLeader.com Details Only 30% of business leaders worldwide are satisfied with their leadership development programs. That fact has been keeping me up at night.How do we close this gap?Before we dive in, it’s important to note that the best leaders and the best organizations are NEVER satisfied! That is, the best always want to do better––no matter how good they are.Now there are many reasons for the low level of satisfaction. Today we’re going to zero in on the one that is most within your control. Focus on this one thing and your leadership development will be more effective…DISCIPLINE.Effective leadership development requires continual commitment on the part of the individual and the continual support of the organization.I’ve seen too many leadership development programs that depend on “one-off” training with little or no follow-up.You don’t forge leaders at a conference or a weekend seminar. That may sound strange coming from someone who makes a living speaking at conferences and conducting seminars––but it’s true!Because that’s what I do, I understand the constraints. In a conference keynote, I have one goal and one goal only: to inspire people to think about the most important aspects of human-centric leadership. Sure, I also share a few strategies along the way, but I don’t expect people to leave a one hour presentation with a comprehensive action plan.In a seminar or workshop we can dive a little deeper. We develop specific action steps, analyze them for viability and probability of success and leave with a plan…But will you do it?In our workshops we have purposely chosen a specific word for these action steps…DISCIPINES.Why this word? Because it takes us beyond any to-do or checklist. It means we are going to focus on areas that we are able and willing to embed in our daily lives.That’s DISCIPLINE.My martial arts life taught me that DISCIPLINE is the development and PRACTICE of meaningful and purposeful habits. Given the constraints of space here––let’s focus on this idea of “practice.”Psychologists today are patting themselves on the backs for “discovering” the secret to excellence in human performance. I’ve read it in a half-dozen recent leadership books. It’s said many ways. Here’s a great example:“If you want a rough metric of what it’ll take to achieve the highest level of expertise, the estimate is about 10,000 hours of practice over a period of ten years. That’s about 2.7 hours a day, every day for ten years.”That one comes from Jim Kouzes and Barry Posner; respected researchers and authors of the wonderful book, The Leadership Challenge.They’re right. I’m not going to argue the substance. I’m just always puzzled that so much energy is devoted to “discovering” what martial artists have known for thousands of years!Bruce Lee neatly summed up these thousands of years of martial philosophy in this simple, powerful observation:“I don’t fear the man who knows 10,000 kicks. I fear the man who practiced one kick 10,000 times.”Leadership is a practice. And it must be practiced––continually. Conferences, seminars, workshops––books, videos and online programs are all extremely valuable. But these are the means––not the ends! This is where you study and learn the skills, behaviors and best practices that help you grow and develop as a leader. Then you’ve got to embed meaningful and purposeful habits in your daily leadership practice…DISCIPLINE.There are two essential components of effective performance:LearningPracticeIf you want to learn, grow and develop as a leader––and these days you’d better unless you want to be rendered obsolete, you’ve got to be willing to learn. And you’ve got to commit yourself to continual practice.On the organization level, one of the most destructive factors leading to disappointing results in leadership development is the lack of ongoing organizational support.If you want your leaders to succeed, you’ve got to give them:Learning and training opportunitiesTime to implement and practice what they’ve learnedFeedback and other means to assess their performance along the wayOpportunities to evolveOne of the most powerful ways to assure continuity in this process is to have people share what they’re learning and doing with others. We encourage people to openly share and expand on whatever they take away from a SENSEI LEADER event. As every good teacher knows––you learn even more when you teach others.“Perfection is NOT a destination. It’s a never-ending process.” Especially in leadership!Effective leaders are the product of continual commitment to this process. It requires discipline, focus and time. Both on the part of the individual––and the organization.last_img read more

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Reichmann’s renaissance

first_imgTo access this article REGISTER NOWWould you like print copies, app and digital replica access too? SUBSCRIBE for as little as £5 per week. Would you like to read more?Register for free to finish this article.Sign up now for the following benefits:Four FREE articles of your choice per monthBreaking news, comment and analysis from industry experts as it happensChoose from our portfolio of email newsletterslast_img

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Morley takes £100m control of Cardiff Bay

first_imgTo access this article REGISTER NOWWould you like print copies, app and digital replica access too? SUBSCRIBE for as little as £5 per week. Would you like to read more?Register for free to finish this article.Sign up now for the following benefits:Four FREE articles of your choice per monthBreaking news, comment and analysis from industry experts as it happensChoose from our portfolio of email newsletterslast_img

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Retailers embrace consumers’ shift to online channels

first_imgAn example of this approach was to give consumers the option to select products online but pick them up in-store, Roy added.The adoption of such a strategy is deemed necessary as consumers are buying more products online during the health crisis. According to the Global Consumer Insights Survey 2020 by PricewaterhouseCoopers (PwC), 69 percent of the Indonesian respondents stated that they were buying more groceries online following the implementation of social restrictions to contain the COVID-19 outbreak.More than half of the respondents, at 57 percent, stated that they were likely to continue shopping online even after the measures were removed.Indonesia has gradually reopened the economy starting in June, despite the continuous rise of COVID-19 cases in the country. The tally of confirmed cases has reached more than 132,800 as of Thursday, with the death toll exceeding 5,900. Indonesian retailers have embraced the need to shift their services online amid the accelerating online shopping trend.Roy Nicholas Mandey, the chairman of the Indonesian Retailers Association (Aprindo), said many of the association’s members had adopted an omnichannel strategy, where retailers integrate offline and online shopping experiences for their consumers’ convenience.“Ninety percent of our members have already changed their businesses by including an omnichannel,” Roy said during a webinar on Thursday. Read also: Consumers wary of visiting shopping centers despite relaxed rules: SurveyPwC survey also showed that online purchases even outpaced in-store purchases as the most popular channel for frequent shopping.When asked about the purchasing frequency using certain shopping channels for their daily and weekly shopping, half of the Indonesian respondents stated that they often used online mobile channels, up from 37 percent in 2019. On the other hand, only 42 percent of the consumers stated they still frequently shopped in-store this year, down from 52 percent in 2019, indicating that in-store shopping is now less preferred for daily to weekly shopping. Retail firm Lotte Mart Indonesia, a subsidiary of South Korean conglomerate Lotte Corp, has undergone a process of digitization prior to the pandemic, but the health crisis has accelerated the development of the company’s online platform and reinstated its digital commitment, according to the firm’s president director, Joseph Buntaran.“The need to have a very good and well-accepted platform is becoming a top one,” Joseph said during the webinar on Thursday.Lotte currently provides e-commerce platform iLotte as well as online shopping service LotteMart Mall for its Indonesian consumers.He added that the company had, in a way, “an unlimited budget” to develop its digital platform as the company acknowledged that the online landscape was going to be very important.Despite this trend, PwC retail and consumer leader Peter Hohtoulas said that physical stores still had a significant role to play in the Indonesian market as the majority of retail purchases were still made offline. “Even as online [purchases] increased since the COVID-19 pandemic, or in fact, over the last two or three years, it still makes up less than 10 percent of total retail sales in Indonesia,” Hohtoulas said, noting that the figure might indicate that consumers still opt to make the less frequent yet higher-value purchases in-store as opposed to online. Indonesian consumers surveyed by PwC reported reasons such as proximity of the store as well as the availability of the items as the reasons to still visit a physical store, while others also cited the experience of physical store shopping as the contributing factor, with 33 percent of respondents stated that it was “a fun pastime.”“I think in-store retail has a vital role to play and can compete well with the online store,” Hohtoulas noted. “Many consider online and offline channels as competing. We don’t see that. I think online and offline should create synergy,” e-commerce giant Tokopedia cofounder and vice chairman Leontinus Alpha Edison said during the webinar.He explained that Tokopedia had been bridging the offline and online shopping experience, such as when it partnered with the annual book bazaar Big Bad Wolf to provide the online experience of the anticipated event following the outbreak of the coronavirus.center_img Topics :last_img read more

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Marina Young: The stories from the many women that regret their abortion should be validated too

first_imgMARINA YOUNG – Founder of Buttons Project – says that the current abortion debate feels like it’s treating her as a criminal – for regretting her abortion. But her experience has been shared by thousands of other women – many of whom have contacted her through the Buttons Project. 28 May 2019Through my own abortion experience and having many stories shared with me from post abortive women, men, siblings and others, the baby aborted is never forgotten. There are often many triggers of remembrance during one’s lifetime and the decision to abort shouldn’t be made lightly.Many factors come into one’s decision, and it often depends on what the woman had to choose from and supports available at the time.Some in the media and ALRANZ want to remove certain safeguards, and their stance often brings the stigma upon other women wanting to share another view regarding their experience. These women then often suffer in silence, unvalidated, vulnerable, and in fear of judgement – as I have.Any changes to the current law must act in the best interests of women’s health and long term mental and emotional wellbeing. Any woman who has had an abortion according to the current law is NOT a criminal. Many women I have spoken with don’t talk about the so-called “hoops” to go through for an abortion. It is more about the lack of honest informed consent and information which is the biggest issue.For many, following an abortion there are feelings of depression, an inner void, grief, physical problems, anxiety, self-harm and suicidal ideation to name a few. Sometimes straight away, or feelings can be suppressed for months or years.We need to take the abortion research seriously. People don’t like having to say that it is a mental health issue, but we need to take account of the women’s mental health. Removing certain safe guards around abortion will not do that and ignores all the research which shows it can harm women.  The decision to abort shouldn’t be taken lightly, when at the end of the day two lives are being affected.For me, the counsellor at the abortion clinic, just agreed with all my fears and gave me no alternatives to choose from. So I continued on this “conveyor belt” of destruction, treated like another number, had a surgical abortion and was awake through the whole procedure. It was a traumatic experience. I had no follow up and suffered in silence for years with feelings of depression, low self-worth, anger, grief and loss. I was not alone in this, as many women have experienced the same and have asked – Who can I reach out to? Who will truly understand what I am going through? A person starts to heal, the moment they feel they have been heard. Their abortion loss needs to be acknowledged and feelings of grief/loss validated. The current abortion debate feels like it’s treating ME as a criminal – for regretting my abortion. But my experience has been shared by thousands of other women – many of whom have contacted me through the Buttons Project.For many the abortion wasn’t the quick fix they thought it was and these babies are not forgotten.  Abortion is such a life-changing event for many and I believe we are just touching the tip of an iceberg of loss.I feel that for whatever reason you choose to abort, there is no denying it is a mental health issue, a battle of mind and body, because you are taking the life of your baby. As I did 33 years ago.I know we can still do so much better for women. It is a momentous and challenging decision affecting her and this new life.We should always choose life!last_img read more

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